Search Clinical Trials
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YES Study - Newly Diagnosed/Metastatic Intervention
Dana-Farber Cancer Institute
Breast Cancer
Symptom, Behavioral
This research study is being done to monitor common symptoms and behavior, and to provide
supportive care information and peer support, as well as research opportunities for young
women ages of 18-39 years old who have been diagnosed with stage 0-IV stage breast cancer
using... expand
This research study is being done to monitor common symptoms and behavior, and to provide supportive care information and peer support, as well as research opportunities for young women ages of 18-39 years old who have been diagnosed with stage 0-IV stage breast cancer using a web-based portal (YES), built for smartphones, tablets, and computers. Type: Interventional Start Date: Sep 2020 |
Trial of Naproxen Sodium for the Treatment of OCD in Children With PANDAS
Massachusetts General Hospital
PANDAS
Anxiety Disorder
Autoimmune Diseases
Obsessive-Compulsive Disorder
This project aims to rigorously evaluate a potential treatment for inflammation-related
Obsessive-Compulsive Disorder (OCD) symptoms in children. To accomplish this goal, the
investigators will conduct a double-blind, randomized, placebo-controlled trial of Naproxen
Sodium,... expand
This project aims to rigorously evaluate a potential treatment for inflammation-related Obsessive-Compulsive Disorder (OCD) symptoms in children. To accomplish this goal, the investigators will conduct a double-blind, randomized, placebo-controlled trial of Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID) in participants diagnosed with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). This research fills a gap in the empirical evidence base for the treatment of PANDAS, and will add to a growing literature of empirically-derived practices for PANDAS. Type: Interventional Start Date: Oct 2020 |
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell...
North American Consortium for Histiocytosis
Langerhans Cell Histiocytosis
The LCH-IV is an international, multicenter, prospective clinical study for pediatric
Langerhans Cell Histiocytosis LCH (age < 18 years).
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The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years). Type: Interventional Start Date: Nov 2016 |
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
Massachusetts General Hospital
Chronic Kidney Disease
Acute Myeloid Leukemia (AML)
Acute Lymphoblastic Leukemia (ALL)
Chronic Myelogenous Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
The main purpose of this study is to examine the outcome of a combined bone marrow and kidney
transplant from a partially matched related (haploidentical or "haplo") donor. This is a
pilot study, you are being asked to participate because you have a blood disorder and kidney... expand
The main purpose of this study is to examine the outcome of a combined bone marrow and kidney transplant from a partially matched related (haploidentical or "haplo") donor. This is a pilot study, you are being asked to participate because you have a blood disorder and kidney disease. The aim of the combined transplant is to treat both your underlying blood disorder and kidney disease. We expect to have about 10 people participate in this study. Additionally, because the same person who is donating the kidney will also be donating the bone marrow, there may be a smaller chance of kidney rejection and less need for long-term use of anti-rejection drugs. Traditionally, very strong cancer treatment drugs (chemotherapy) and radiation are used to prepare a subject's body for bone marrow transplant. This is associated with a high risk for serious complications, even in subjects without kidney disease. This therapy can be toxic to the liver, lungs, mucous membranes, and intestines. Additionally, it is believed that standard therapy may be associated with a higher risk of a complication called graft versus host disease (GVHD) where the new donor cells attack the recipient's normal body. Recently, less intense chemotherapy and radiation regimens have been employed (these are called reduced intensity regimens) which cause less injury and GVHD to patients, and thus, have allowed older and less healthy patients to undergo bone marrow transplant. In this study, a reduced intensity regimen of chemotherapy and radiation will be used with the intent of producing fewer toxicities than standard therapy. Typical therapy following a standard kidney transplant includes multiple lifelong medications that aim to prevent the recipient's body from attacking or rejecting the donated kidney. These are called immunosuppressant drugs and they work by "quieting" the recipient's immune system to allow the donated kidney to function properly. One goal in our study is to decrease the duration you will need to be on immunosuppressant drugs following your kidney transplant as the bone marrow transplant will provide you with the donor's immune system which should not attack the donor kidney. Type: Interventional Start Date: Nov 2012 |
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
Diabetes Mellitus, Type 1
Impaired Hypoglycemic Awareness
Severe Hypoglycemia
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in
participants with Type 1 diabetes mellitus (T1D) and impaired awareness of hypoglycemia (IAH)
and severe hypoglycemia.
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This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes mellitus (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia. Type: Interventional Start Date: Mar 2021 |
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
University of Iowa
Charcot-Marie-Tooth Disease, Type Ia (Disorder)
HMSN
This project includes two projects. One is looking for new genes that cause Charcot Marie
Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the
symptoms a person has.
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This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has. Type: Observational Start Date: May 2010 |
Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's...
Massachusetts General Hospital
Barrett Esophagus
The investigators have developed a new technology, termed in-vivo laser capture
microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening
for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction
of EAC risk.... expand
The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction of EAC risk. The device is a tethered capsule endomicroscope (TCE) that implements optical coherence tomography (OCT) to grab 10-mm-resolution, cross-sectional microscopic images of the entire esophagus after the capsule is swallowed. This OCT-based TCE technology is used in unsedated patients to visualize images of BE and dysplastic BE. During the IVLCM procedure, TCE images of abnormal BE tissue are identified in real time and selectively adhered onto the device. When the capsule is removed from the patient, these tissues, targeted based on their abnormal OCT morphology, are sent for genomic analysis. By enabling the precise isolation of aberrant esophageal tissues using a swallowable capsule, this technology has the potential to solve the major problems that currently prohibit adequate BE screening and prevention of Esophageal Adenocarcinoma EAC. Type: Interventional Start Date: Dec 2017 |
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System
Massachusetts General Hospital
Barrett's Esophagus
The goal of this research is to test a distal scanning capsule and a compact redesigned
version of the OFDI imaging system in healthy and BE subjects to assess ease of use, safety
and feasibility in preparation for its use in a multicenter clinical trial.
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The goal of this research is to test a distal scanning capsule and a compact redesigned version of the OFDI imaging system in healthy and BE subjects to assess ease of use, safety and feasibility in preparation for its use in a multicenter clinical trial. Type: Interventional Start Date: Apr 2016 |
Proton RT for the Treatment of Pediatric Rhabdomyosarcoma
Massachusetts General Hospital
Rhabdomyosarcoma
The main purpose of this study is to see if using proton beam radiation therapy instead of
photon beam radiation therapy can reduce side effects from radiation treatment for
rhabdomyosarcoma. Photon beam radiation is the standard type of radiation for treating most
rhabdomyosarcoma... expand
The main purpose of this study is to see if using proton beam radiation therapy instead of photon beam radiation therapy can reduce side effects from radiation treatment for rhabdomyosarcoma. Photon beam radiation is the standard type of radiation for treating most rhabdomyosarcoma and many other types of cancer. Photon beam radiation enters the body and passes through healthy tissue, encounters the tumor, then leaves the body through healthy tissue. A beam of proton radiation enters the body and passes through healthy tissue, encounters tumor, but then stops. This means that less healthy tissue is affected by proton beam radiation than by photon beam radiation. Type: Interventional Start Date: Oct 2004 |
Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac...
Massachusetts General Hospital
Cardiovascular Diseases
Oxidative Stress
Endothelial Dysfunction
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric
Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical
Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to
receive... expand
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This ancillary study aims to assess the effects of Nitric Oxide on plasma reduction-oxidation reactions of patients undergoing cardiac surgery requiring prolonged cardiopulmonary bypass. Type: Interventional Start Date: Jul 2019 |
Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
Spaulding Rehabilitation Hospital
Spinal Cord Injuries
Polytrauma
Burns
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose
extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and
burn injury. The goal is to provide the same level of pain relief with a reduced opioid
intake... expand
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effects as well as the risk of addiction associated with opioid treatment. Type: Interventional Start Date: Aug 2022 |
Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases
Institute of Bioengineering and Bioimaging (IBB)
Congestive Heart Failure
Asthma
Chronic Obstructive Pulmonary Disease
Cystic Fibrosis
In this project, Institute of Bioengineering & Bioimaging (IBB), A*STAR would like to
collaborate with Massachusetts General Hospital to aggregate patient data and to further
develop its software algorithm using machine learning and statistical models for predicting
exacerbations... expand
In this project, Institute of Bioengineering & Bioimaging (IBB), A*STAR would like to collaborate with Massachusetts General Hospital to aggregate patient data and to further develop its software algorithm using machine learning and statistical models for predicting exacerbations and deterioration on 60 patients with cardiopulmonary diseases. Type: Interventional Start Date: Apr 2022 |
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases...
Massachusetts General Hospital
Colorectal Cancer
This research study is studying a drug in combination with radiation therapy as a possible
treatment for hepatic metastases from colorectal cancer.
The interventions involved in this study are:
- Trifluridine (TAS-102)
- Radiation Therapy
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This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer. The interventions involved in this study are: - Trifluridine (TAS-102) - Radiation Therapy Type: Interventional Start Date: Oct 2017 |
Rare and Atypical Diabetes Network
University of South Florida
Diabetes Mellitus
Diabetes Mellitus Progression
Glucose Intolerance
Glucose Metabolism Disorders
Metabolic Disease
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of
atypical diabetes.
The objective of this study is to define new forms of diabetes and the unique mechanisms
underlying these forms of atypical diabetes. The specific aims are to:... expand
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes. Type: Observational Start Date: Sep 2020 |
Thoracoabdominal Asynchrony and Respiratory Distress
Massachusetts General Hospital
Respiratory Insufficiency
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors
attached to the abdomen and chest of a child will provide information regarding
thoracoabdominal asynchrony (TAA), a major component of respiratory distress, and ultimately
help guide... expand
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of respiratory distress, and ultimately help guide a clinician to initiate, escalate, de-escalate, or stop respiratory support interventions. AIMS To determine if the TAA-monitoring device can be used to detect differences in respiratory synchrony in a manner that is clinically applicable. The investigators hope that the device will detect 1) major asynchrony events in a timely manner so as to prompt clinician intervention during future use; and 2) asynchrony events that may be less visible to the naked eye that may be precursors to more severe events. Type: Interventional Start Date: Oct 2020 |
Incidence of Difficult Airway and Difficult Neuraxial Placement in Obstetric Patients
Brigham and Women's Hospital
Indication for Care or Intervention Related to Labor or Delivery With Baby Delivered
Anesthesiologists commonly administer pain relief during labor or providing anesthesia for
cesarean delivery. Two main methods are used to achieve these goal: "Regional anesthesia"
where the mother is given medication through a needle or catheter in her back and the mother... expand
Anesthesiologists commonly administer pain relief during labor or providing anesthesia for cesarean delivery. Two main methods are used to achieve these goal: "Regional anesthesia" where the mother is given medication through a needle or catheter in her back and the mother is kept awake, or "General anesthesia", where the mother is given intravenous medication and is kept asleep. Regional anesthesia uses a needle to enter a narrow space in the mother's back where medications can be given. In some patients, it takes longer to find this target space in the back. In emergency situation, however, there is often little time to find this space, and the backup method would be the general anesthesia technique. If general anesthesia is required, a breathing tube needs to be inserted to help support the mother's breathing. In some patients, it is harder to insert the breathing tubes, so knowing this in advanced helps anesthesiologists create a safe plan for the patients. A lot of research has been done to determine factors that would predict which patients would need more time and preparation for general anesthesia and regional anesthesia. The purpose of this study is to study how common it is for the pregnant patients who have a difficult regional and general anesthesia. Type: Observational Start Date: Jul 2014 |
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
Massachusetts General Hospital
Metabolic Disease
The goal of this study is to understand how exogenous kisspeptin affects metabolism by
evaluating responses to an hyperglycemic clamp
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The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp Type: Interventional Start Date: Jun 2022 |
Prevalence of Sleep Apnea and Atrial Fibrillation
Brigham and Women's Hospital
Sleep Apnea
Atrial Fibrillation
The investigators will screen consecutive patients presenting to the atrial fibrillation
clinic for sleep apnea using a FDA-approved home sleep testing device, WatchPAT to determine
prevalence of sleep apnea in a clinic-based sample.
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The investigators will screen consecutive patients presenting to the atrial fibrillation clinic for sleep apnea using a FDA-approved home sleep testing device, WatchPAT to determine prevalence of sleep apnea in a clinic-based sample. Type: Observational Start Date: Feb 2022 |
Dabrafenib + Trametinib + PDR001 In Colorectal Cancer
Massachusetts General Hospital
Metastatic Colorectal Cancer
This research study is studying a combination of drugs as a possible treatment for metastatic
colorectal cancer characterized by BRAF V600E mutation.
The names of the study drugs involved in this study are:
- Dabrafenib
- Trametinib
- PDR001... expand
This research study is studying a combination of drugs as a possible treatment for metastatic colorectal cancer characterized by BRAF V600E mutation. The names of the study drugs involved in this study are: - Dabrafenib - Trametinib - PDR001 Type: Interventional Start Date: Oct 2018 |
Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus
Massachusetts General Hospital
Gestational Diabetes
The hypothesis for this study is that women with different physiologic subtypes of
gestational diabetes (GDM) (insulin secretion deficit vs. insulin sensitivity deficit) will
differ in their glycemic responses to meals with different portions of dietary
macronutrients. Investigators... expand
The hypothesis for this study is that women with different physiologic subtypes of gestational diabetes (GDM) (insulin secretion deficit vs. insulin sensitivity deficit) will differ in their glycemic responses to meals with different portions of dietary macronutrients. Investigators will determine GDM subtype based on glucose and insulin levels taken at multiple time points during an oral glucose tolerance test. Participants will consume two meals with different macronutrient content while wearing a continuous glucose monitor which will allow investigators to assess the glycemic response to the meals. Type: Interventional Start Date: Feb 2020 |
Struvite Stones Antibiotic Study
University of British Columbia
Kidney Stones
The aim of this research is to determine an effective antibiotic regimen following definitive
surgical therapy of kidney stones caused by bacterial infection (struvite stones).
expand
The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones). Type: Interventional Start Date: Mar 2015 |
A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Triple Negative Breast...
Massachusetts General Hospital
Triple Negative Breast Cancer
Residual Disease
This research study involves Niraparib as a possible treatment for triple negative breast
cancer.
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This research study involves Niraparib as a possible treatment for triple negative breast cancer. Type: Interventional Start Date: Jul 2019 |
Pilot Study of a Multimodal Prehabilitation Pancreatic Cancer Program
Massachusetts General Hospital
Pancreatic Ductal Adenocarcinoma
The purpose of this research is to explore the benefits of an exercise and nutrition program
during total neoadjuvant therapy (TNT) in preparation for surgery for participants that have
pancreatic ductal adenocarcinoma (PDAC)
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The purpose of this research is to explore the benefits of an exercise and nutrition program during total neoadjuvant therapy (TNT) in preparation for surgery for participants that have pancreatic ductal adenocarcinoma (PDAC) Type: Interventional Start Date: Aug 2019 |
Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung Cancer
Massachusetts General Hospital
Lung Cancer
This research study is studying a combination of drugs as a possible treatment for
EGFR-Mutated Advanced Lung Cancer.
The names of the study drugs involved in this study are Niraparib and Osimertinib.
expand
This research study is studying a combination of drugs as a possible treatment for EGFR-Mutated Advanced Lung Cancer. The names of the study drugs involved in this study are Niraparib and Osimertinib. Type: Interventional Start Date: Jun 2019 |
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly...
Arog Pharmaceuticals, Inc.
Newly Diagnosed FLT3 Mutated AML
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with
that of midostaurin when administered following induction chemotherapy, consolidation
chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3
mutation.... expand
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. Once the FLT3 mutation status is confirmed and additional eligibility is established, subject will be randomized and enter into the treatment phase. Type: Interventional Start Date: Aug 2018 |
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