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Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal...
W.L.Gore & Associates
Thoracoabdominal Aortic Aneurysm
Prospective, non-randomized, , multicenter study with two independent arms:
- Primary Study Arm - TAAA and Pararenal aneurysms requiring only TAMBE System.
Hypothesis-driven analysis.
- Up to 65 additional subjects may be implanted in Continued Access Phase under
the... expand
Prospective, non-randomized, , multicenter study with two independent arms: - Primary Study Arm - TAAA and Pararenal aneurysms requiring only TAMBE System. Hypothesis-driven analysis. - Up to 65 additional subjects may be implanted in Continued Access Phase under the Primary Study Arm only - Secondary Study Arm - TAAA requiring TAMBE System and CTAG Device(s). Non hypothesis-driven analysis. Minimum: 122 implanted subjects. Maximum: 202 implanted subjects with up to 65 additional subjects implanted in Continued Access (Primary Study arm) Type: Interventional Start Date: Jun 2019 |
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3...
Turning Point Therapeutics, Inc.
Locally Advanced Solid Tumors
Metastatic Solid Tumors
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs),
the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2
dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies
harboring an ALK, ROS1, NTRK1, NTRK2,... expand
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Midazolam DDI substudy will examine effect of of repotrectinib on CYP3A induction. Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blinded Independent Central Review (BICR) of repotrectinib in each subject population expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. The secondary objective will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS) and clinical benefit rate (CBR) of repotrectinib in each expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Type: Interventional Start Date: Mar 2017 |
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Leigh R. Hochberg, MD, PhD.
Tetraplegia
Spinal Cord Injuries
Amyotrophic Lateral Sclerosis
Brain Stem Infarctions
Locked in Syndrome
The purpose of this study is to obtain preliminary device safety information and
demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to
control a computer cursor and other assistive devices with their thoughts. expand
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts. Type: Interventional Start Date: May 2009 |
IMPRoving Outcomes in Vascular DisEase- Aortic Dissection
Duke University
Type B Aortic Dissection
The goal of this clinical trial is to determine whether an upfront invasive strategy of
TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause
death or major aortic complications compared to an upfront conservative strategy of
medical therapy with surveillance for deterioration... expand
The goal of this clinical trial is to determine whether an upfront invasive strategy of TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause death or major aortic complications compared to an upfront conservative strategy of medical therapy with surveillance for deterioration in patients with uncomplicated type B aortic dissection. Type: Interventional Start Date: Apr 2024 |
Examining Distinct Immunophenotypes to Validate and Enhance Rational Treatment in Systemic Lupus
National Institute of Allergy and Infectious Diseases (NIAID)
Systemic Lupus Erythematosus
The primary purpose of this study is to evaluate the potential effectiveness of 24 weeks
of MMF within previously discovered immunologically defined subsets of SLE patients.
Treatment effects will be evaluated within the individual immunologically-homogenous
subsets defined at screening. This study... expand
The primary purpose of this study is to evaluate the potential effectiveness of 24 weeks of MMF within previously discovered immunologically defined subsets of SLE patients. Treatment effects will be evaluated within the individual immunologically-homogenous subsets defined at screening. This study will also explore and compare pre-randomization gene expression patterns among responders and non-responders to MMF and MMF plus voclosporin, use comprehensive immunophenotyping to study the immunologic changes that accompany treatment- induced disease improvement and to better understand immunologic changes associated with the loss of clinical response. Type: Interventional Start Date: Oct 2022 |
Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events
Center for International Blood and Marrow Transplant Research
Acute Myeloid Leukemia in Remission
Prospective determination of the clinical utility of measurable residual disease (MRD)
testing for relapse and survival of patients with acute myeloid leukemia (AML) undergoing
allogeneic hematopoietic cell transplantation (alloHCT). expand
Prospective determination of the clinical utility of measurable residual disease (MRD) testing for relapse and survival of patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic cell transplantation (alloHCT). Type: Observational Start Date: Aug 2022 |
Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
Massachusetts General Hospital
Atherosclerosis
Stress
Inflammation
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on
atherosclerotic plaque inflammation in adults, as quantified by positron emission
tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased
psychosocial stress. expand
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress. Type: Interventional Start Date: Sep 2018 |
TRISCEND II Pivotal Trial
Edwards Lifesciences
Tricuspid Valve Regurgitation
Tricuspid Valve Insufficiency
Tricuspid Valve Disease
Heart Valve Diseases
Cardiovascular Diseases
Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid
valve replacement system expand
Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system Type: Interventional Start Date: Apr 2021 |
Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or...
MapKure, LLC
Solid Tumor
B-Raf Mutation-Related Tumors
The purpose of this study is to evaluate the safety, tolerability, and antitumor activity
of BGB-3245 in participants with advanced or refractory solid tumors expand
The purpose of this study is to evaluate the safety, tolerability, and antitumor activity of BGB-3245 in participants with advanced or refractory solid tumors Type: Interventional Start Date: Feb 2020 |
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
Massachusetts General Hospital
Tumor Surgery
This study is being conducted to decrease the rate of surgical wound complications. The
investigators are studying the effects that caloric restriction has on decreasing the
rate of surgical wound complications. expand
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications. Type: Interventional Start Date: Jun 2016 |
Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
Massachusetts General Hospital
Acute Neurological Injury
Emotional Distress
The purpose of the present investigation is to test the efficacy of a brief (6 sessions)
dyadic (patient and caregiver together) intervention to prevent chronic emotional
distress in at risk dyads admitted to a Neuroscience Intensive Care Unit with an acute
brain injury. Through this study, we seek... expand
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience Intensive Care Unit with an acute brain injury. Through this study, we seek to solve the unmet need of preventing chronic emotional distress in Neuroscience Intensive Care Unit (NICU) dyads through a feasible, acceptable and credible program, and ideally improve the recovery trajectory and dyads' overall quality of life. Type: Interventional Start Date: Dec 2021 |
Virtual Health Insurance Navigation Pilot Program for Colorectal Survivors
Massachusetts General Hospital
Health Insurance
Colorectal Cancer Survivors
This trial aims to assess the feasibility and acceptability of colorectal survivors
approached and engaged in HINT and aims to assess the preliminary efficacy of HINT to
improve 1) health insurance literacy and 2) financial burden related to medical cost
concerns colorectal survivors. The study investigators... expand
This trial aims to assess the feasibility and acceptability of colorectal survivors approached and engaged in HINT and aims to assess the preliminary efficacy of HINT to improve 1) health insurance literacy and 2) financial burden related to medical cost concerns colorectal survivors. The study investigators propose that, compared to the control arm (who will receive a health insurance information guide, but will not receive the navigation intervention), participants in the HINT intervention arm will have improved health insurance literacy and decreased financial distress related to medical costs. Type: Interventional Start Date: Nov 2021 |
PET Fibrin Imaging of DVT and PE
Peter Caravan
Pulmonary Embolism
Deep Vein Thrombosis
Venous Thromboembolism
This study aims to investigate a novel positron emission tomography(PET)-probe for
imaging of fresh intravascular blood clots in pulmonary embolism (PE) and deep venous
thrombosis (DVT). expand
This study aims to investigate a novel positron emission tomography(PET)-probe for imaging of fresh intravascular blood clots in pulmonary embolism (PE) and deep venous thrombosis (DVT). Type: Interventional Start Date: May 2019 |
Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent...
Regeneron Pharmaceuticals
Recurrent Ovarian Cancer
Recurrent Fallopian Tube Cancer
Recurrent Primary Peritoneal Cancer
Recurrent Endometrial Cancer
The main purpose of this study is to:
- Learn about the safety of REGN4018 and to find out what dose of REGN4018 can be
given alone or with cemiplimab to patients with ovarian cancer or cancer of the
uterus
- The study will also look at the levels of REGN4018 and/or cemiplimab... expand
The main purpose of this study is to: - Learn about the safety of REGN4018 and to find out what dose of REGN4018 can be given alone or with cemiplimab to patients with ovarian cancer or cancer of the uterus - The study will also look at the levels of REGN4018 and/or cemiplimab in your body and measure how well your body can remove the study drug(s). This is called pharmacokinetics - The study will also look at any signs that REGN4018 alone or with cemiplimab can treat recurrent advanced ovarian cancer or cancer of the uterus - To find out how safe and tolerable the sarilumab pretreatment is, in combination with REGN4018 and cemiplimab Type: Interventional Start Date: May 2018 |
Studying the Neuronal Basis of Human Social Cognition
Massachusetts General Hospital
Neurosciences
This proposal aims to study the role that the dorsal prefrontal cortex plays in human
social cognition. expand
This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition. Type: Interventional Start Date: May 2022 |
Lenvatinib in Locally Advanced Invasive Thyroid Cancer
Massachusetts Eye and Ear Infirmary
Differentiated Thyroid Cancer
Advanced Cancer
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib
on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid
cancer (DTC).
This research study involves a study drug called lenvatinib expand
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC). This research study involves a study drug called lenvatinib Type: Interventional Start Date: Mar 2021 |
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
MedtronicNeuro
Epilepsy
The purpose of this post-approval study is to further evaluate the long-term safety and
effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly
implanted participants through 3 years of follow-up. expand
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up. Type: Interventional Start Date: Mar 2020 |
Spinraza in Adult Spinal Muscular Atrophy
Washington University School of Medicine
Spinal Muscular Atrophy
Spinal Muscular Atrophy Type II
Spinal Muscular Atrophy Type 3
This is a longitudinal, observational study of adult patients with genetically confirmed
chromosome 5q SMA to examine the safety, tolerability, and effectiveness of SPINRAZA®
(nusinersen) for up to 30 months. expand
This is a longitudinal, observational study of adult patients with genetically confirmed chromosome 5q SMA to examine the safety, tolerability, and effectiveness of SPINRAZA® (nusinersen) for up to 30 months. Type: Observational Start Date: Aug 2018 |
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral...
Minoryx Therapeutics, S.L.
Cerebral Adrenoleukodystrophy (cALD)
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male
Subjects with Cerebral Adrenoleukodystrophy. expand
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy. Type: Interventional Start Date: Jul 2023 |
Psychosocial Mobile App for Chronic Graft-Versus-Host Disease
Massachusetts General Hospital
Chronic Graft-Versus-Host Disease
Allogeneic Stem Cell Transplant
The purpose of this research study is to see whether a psychosocial mobile app called
Horizons is effective at improving quality of life, symptom burden, psychological
distress, and coping in patients living with chronic graft-versus host disease (GVHD) expand
The purpose of this research study is to see whether a psychosocial mobile app called Horizons is effective at improving quality of life, symptom burden, psychological distress, and coping in patients living with chronic graft-versus host disease (GVHD) Type: Interventional Start Date: Jan 2023 |
Biology of Young Lung Cancer Study: The YOUNG LUNG Study
Dana-Farber Cancer Institute
Non Small Cell Lung Cancer
Small Cell Lung Carcinoma
The purpose of this research study is to learn more about lung cancer (NSCLC or SCLC)
diagnosed in adults at ages 45 or younger. expand
The purpose of this research study is to learn more about lung cancer (NSCLC or SCLC) diagnosed in adults at ages 45 or younger. Type: Observational Start Date: Jan 2023 |
An Ethical Approach to Detecting Covert Consciousness
Massachusetts General Hospital
Disorder of Consciousness
This study aims to develop an ethical approach to developing and deploying novel
neurotechnologies to aid in the detection of consciousness and prediction of recovery
after brain injury. expand
This study aims to develop an ethical approach to developing and deploying novel neurotechnologies to aid in the detection of consciousness and prediction of recovery after brain injury. Type: Observational Start Date: Feb 2022 |
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Massachusetts General Hospital
Multiple Sclerosis
Our overall objective is to obtain an initial assessment of the potential value of using
[18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis:
- Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with
multiple sclerosis (MS). Hypothesis 1: Administration... expand
Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: - Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administration of [18F]3F4AP will result in no changes in vitals or other adverse events. - Aim 2) Assess the pharmacokinetics of a bolus infusion of [18F]3F4AP in humans including healthy volunteers and MS patients. Hypothesis 2: the pharmacokinetics of [18F]3F4AP at the whole brain level will be similar in controls and MS subjects. The kinetics in demyelinated lesions will be slower than in healthy control areas. - Aim 3) Assess the reproducibility of [18F]3F4AP in humans. Hypothesis 3: the test/retest variability of [18F]3F4AP within the same subject will be lower than 10%. - Aim 4) Correlate MR brain images with [18F]3F4AP PET brain images. Hypothesis 4A: all the lesions seen on the MRI will show increased signal (VT or SUV) on the PET images. Hypothesis 4B: some of the lesions on the MRI will show increased signal (VT or SUV) on the PET but not all. - Aim 5) Correlate [18F]3F4AP PET signal with neuropsychological testing in people with MS. Hypothesis 5: increased PET signal (VT or SUV) will correlate with impaired Single Digit Modality Test (SDMT) scores. - Aim 6) Correlate [18F]3F4AP PET signal with EDSS score in people with MS. Hypothesis 6: increased PET signal (VT or SUV) will correlate with higher EDSS scores. Type: Interventional Start Date: Mar 2021 |
Epidermal Skin Grafts to Improve Healing In Radiation Wounds
Massachusetts General Hospital
Radiation Dermatitis
Patients undergoing radiation for the treatment of malignancies may suffer from side
effects to the skin in the form of radiation dermatitis. This can lead to local wound
formation with poor healing. Treatment options for the resulting wound can range from
watchful waiting to more aggressive debridement... expand
Patients undergoing radiation for the treatment of malignancies may suffer from side effects to the skin in the form of radiation dermatitis. This can lead to local wound formation with poor healing. Treatment options for the resulting wound can range from watchful waiting to more aggressive debridement and secondary grafting. Epidermal grafting is a technique in which autologous epidermis is used to cover wounds that are larger than the donor site. Previous studies have demonstrated that this is an effective treatment for different wounds and ulcers but its utility has not yet been evaluated for the treatment of radiation induced injuries. The CelluTome Epidermal Grafting System is a semi automated device that allows easy formation of epidermal Blister. Our study will evaluate the efficacy of epidermal grafts collected using the CelluTome device in the treatment of radiation dermatitis. Type: Interventional Start Date: Jan 2021 |
Genome Environment Microbiome and Metabolome in Autism Study
Massachusetts General Hospital
Autism Spectrum Disorder
GEMMA is a multicenter longitudinal observational study that follows children who are
genetically at-risk of developing autism for their first three years of life, seeking to
identify potential biomarkers predictive of autism development in the blood, stool, urine
and saliva. The biomarkers identified... expand
GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and possible solutions for alleviating and/or preventing ASD and ASD-related symptoms in patients in the future. Type: Observational Start Date: Jul 2019 |
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