Mass General - Division of Clinical Research

Eligibility

Eligible Ages

Over 14 Years

Eligible Genders

All

Accepts Healthy Volunteers

No

Criteria

Inclusion

1. Age ≥ 14 years old at time of signing informed consent

2. Able to provide informed consent (and assent for participants <18 years old)

3. Documentation of a CF diagnosis as evidenced by one or more clinical features
consistent with the CF phenotype and one or more of the following criteria:

- Sweat chloride equal to or greater than 60 mmol/liter by quantitative
pilocarpine iontophoresis test (QPIT) (when not taking a cystic fibrosis
transmembrane conductance regulator (CFTR) modulator)

- Two well-characterized mutations in the CFTR gene

4. Clinical diagnosis of CFRD, defined as a person with CF and diabetes mellitus,
treated with insulin for ≥3 months prior to screening

5. Using the same insulin regimen for ≥1 month prior to screening and collection of
baseline CGM data, with no plans to change regimen during the study: either multiple
daily injections of insulin (MDI), basal-only without bolus insulin, an insulin pump
without automation, or an automated insulin delivery (AID) system other than the BP
(which is an exclusion)

6. Total daily insulin dose must be ≥0.1 units/kg

7. Able to speak and read English sufficient to understand the pump user interface and
provide written materials for safe operation of the BP

• For pediatric participants, this applies to both the participant and caregiver

8. For participants <18 years old, living with one or more parent/legal guardian
knowledgeable about emergency procedures for severe hypoglycemia. A designated care
partner must be willing to be linked to the participant's Dexcom Follow application
with location sharing on.

9. For participants >18 years old who live alone, participant has a relative or
acquaintance who lives within 30 minutes of participant and is willing to be
contacted to check on participant if study staff feel that participant may be
experiencing a medical emergency and cannot be reached. A designated care partner
must be willing to be linked to the participant's Dexcom Follow application with
location sharing on.

10. No use of a non-insulin glucose-lowering medication, except metformin, that is not
approved for use in T1D within 3 months prior to signing informed consent and
willing to not use any such medications during the course of the trial. Note: such
drugs cannot be used even if prescribed for weight loss rather than
glucose-lowering.

11. If not currently using a rapid-acting insulin that is approved for use in the iLet
pump, willing and able to switch to an approved insulin when using the BP.

12. Participant has commercial glucagon available for treatment of severe hypoglycemia
or will obtain it prior to randomization

13. Willing to authorize the study team to contact the participant's primary physician
to inform them about their participation in this study.

14. Enrolled in the Cystic Fibrosis Foundation Patient Registry (participants may enroll
in the Registry at the time of enrollment if not already enrolled).

15. No plans for trips of more than 14 consecutive days outside the United States during
the period of study participation

16. Investigator believes that the participant can safely use the iLet and will follow
the protocol • The investigator will take into account the participant's HbA1c level
(there is no upper limit for eligibility), compliance with current diabetes
management, prior acute diabetic complications, cognitive ability, and general
medical condition. For this reason, there is no upper limit on HbA1c specified for
eligibility.

Exclusion

1. Current use of the BP or an AID system not FDA approved for T1D

2. Known hemoglobinopathy (sickle cell trait is not an exclusion)

3. Current participation in another diabetes-related interventional trial

4. Established history of allergy or severe reaction to adhesive or tape that must be
used in the study

5. Pregnant (positive urine hCG), breast feeding, plan to become pregnant in the next 7
months, or sexually active and can become pregnant but not using contraception

6. Current use of hydroxyurea or unable to avoid hydroxyurea use during the study
(interferes with accuracy of Dexcom sensor)

7. Have started or stopped a CFTR modulator in the 4 weeks prior to screening.

• Modifications of the dosing of a CFTR modulator is acceptable

8. Anticipated lung or liver transplant (on transplant list)

9. Lung or liver transplant within one year prior to screening. If they have had a
transplant more than a year ago, but they:

- Have had a rejection episode occur in prior 8 weeks, individual is excluded.

- Their doses of corticosteroids and/or calcineurin inhibitors have not been
stable for one month prior to enrollment and/or is expected to change
significantly over the course of the study, individual is excluded.

10. Acute pulmonary exacerbation or hospitalization within the 4 weeks prior to
screening or treatment with IV antibiotics in the 4 weeks prior to screening

11. History of a complete pancreatectomy

12. Currently using enteral tube feedings for nutritional support

13. Presence of a medical condition or use of a medication that, in the judgment of the
investigator, clinical protocol chair, or medical monitor, could compromise the
results of the study or the safety of the participant. Conditions to be considered
by the investigator may include the following:

- Alcohol or drug abuse

- Use of prescription drugs that may dull the sensorium, or hinder
decision-making during the period of participation in the study such has
opioids or short-acting benzodiazepines

- Coronary artery disease that is not stable with medical management, including
unstable angina, angina that prevents moderate exercise (e.g., climbing a
flight of stairs) despite medical management; or within the last 12 months
before screening: a history of myocardial infarction, percutaneous coronary
intervention, enzymatic lysis of a presumed coronary occlusion, or coronary
artery bypass grafting

- Congestive heart failure with New York Heart Association (NYHA) Functional
Classification III or IV

- History of TIA or stroke in the last 12 months

- Severe liver disease such as end-stage cirrhosis

- Renal failure requiring dialysis or known eGFR <30

- Untreated or inadequately treated mental illness

- History of untreated or inadequately treated eating disorder within the last 2
years, such as anorexia, bulimia, or diabulimia or omission of insulin to
manipulate weight

- History of intentional, inappropriate administration of insulin leading to
severe hypoglycemia requiring treatment

14. Employed by, or having immediate family members employed by Beta Bionics, or being
directly involved in conducting the clinical trial, or having a direct supervisor at
place of employment who is also directly involved in conducting the clinical trial
(as a study investigator, coordinator, etc.); or having a first-degree relative who
is directly involved in conducting the clinical trial.