Global Prospective, Observational Cohort of Adult Patients with Primary Sclerosing Cholangitis (WIND-PSC Study)
Purpose
Develop an appropriate real-world data comparator cohort to support the design, execution, and serve as an external control for interventional clinical trials in PSC.
Condition
- PSC
Eligibility
- Eligible Ages
- Between 18 Years and 75 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Adult patients between 18 and 75 years of age (inclusive) who can comprehend instructions, follow the study procedures and are willing to sign an Informed Consent Form (ICF). 2. Confirmed clinical diagnosis of large duct PSC based on current AASLD Guidelines (Bowlus 2023).
Exclusion Criteria
- Clinically significant acute or chronic liver disease of an etiology other than PSC (with or without presence of features of AIH). 2. Small-Duct PSC. 3. Clinically diagnosed secondary or IgG4-related sclerosing cholangitis. 4. Clinically diagnosed acute cholangitis and currently receiving treatment. Patients on chronic suppressive antibiotics will be allowed to enroll. 5. UDCA dose >28 mg/kg 6. Evidence of current or historical decompensated cirrhosis based on the following clinical events: - Ascites > Grade 2 and requiring treatment - Esophageal or gastric variceal bleeding requiring hospitalization - Hepatic encephalopathy (as defined by a West Haven score ≥ 2) - Spontaneous bacterial peritonitis defined as ascites absolute neutrophil count >250/mm3 in the absence of an intra-abdominal source of infection - AKI-HRS according to AASLD Guidelines (Flamm 2021) 7. Prior liver transplantation 8. MELD-Na Score >15. For subjects on anticoagulation medication, baseline INR determination for MELD score calculation should take this use into account. 9. Participants with current clinical or laboratory evidence of any severe, progressive, or uncontrolled disease, related or unrelated to PSC and which, in the opinion of the investigator, has an expected survival of less than 48 weeks. 10. Participants who are impaired, incapacitated, or incapable of completing study- related assessments or giving informed consent. 11. Prisoners or participants who are involuntarily incarcerated. 12. Participants who are currently participating in an interventional clinical study. 13. Absence of data in medical records to assess inclusion and exclusion criteria.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Adult patients with a confirmed diagnosis of large duct PSC. | 1. Adult patients between 18 and 75 years of age (inclusive) who can comprehend instructions, follow the study procedures and are willing to sign an Informed Consent Form (ICF). 2. Confirmed clinical diagnosis of large duct PSC based on current AASLD Guidelines. |
Recruiting Locations
Massachusetts General Hospital
Boston, Massachusetts 02114
Boston, Massachusetts 02114
More Details
- Status
- Recruiting
- Sponsor
- PSC Partners Seeking a Cure
Detailed Description
Global, multi-center longitudinal observational cohort study. Collection of prospective clinical data to include liver-related clinical outcomes and safety events, hepatobiliary malignancies, relevant key biomarkers, imaging assessments, PSC-related clinical symptoms, patient-reported outcomes, and medication use in adult patients with PSC.