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Purpose

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 75 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

• Subjects with healthy eyes (age 18 - 75, N = 50)

Exclusion Criteria

  • Subjects with history of eye diseases, and previous eye surgeries. - Subjects with diabetes, glaucoma family history - Subjects allergic to anesthetic eyedrop, especially proparacaine - Subjects with severe allergy - Subjects who have difficulty biting - Subjects who have recurrent corneal erosion Group 2: Inclusion criteria: • Subjects with healthy skin (age 18 - 75, N = 10) Exclusion criteria: • Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition Group 3: Inclusion criteria: • Subjects with healthy gingiva (age 18 - 75, N = 10) Exclusion criteria: • Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition Group 4: Inclusion criteria: • Mild or moderate keratoconus subjects (age 18 - 40, N = 20) Exclusion criteria: • Subjects with K-max above 60 diopters (Pentacam imaging) are excluded

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Healthy cornea 		Optical imaging of the cornea in healthy subjects
  • Device: Optical imaging of the tissues
    OCT vibrography
Experimental
Healthy skin 		Optical imaging of the skin in healthy subjects
  • Device: Optical imaging of the tissues
    OCT vibrography
Experimental
Healthy gingiva 		Optical imaging of the gingiva in healthy subjects
  • Device: Optical imaging of the tissues
    OCT vibrography
Experimental
Keratoconus cornea 		Optical imaging of the cornea in mild and moderate keratoconus
  • Device: Optical imaging of the tissues
    OCT vibrography

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Xu Feng, PhD
617-724-6798
xfeng4@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

Xu Feng, PhD
6177246798
xfeng4@mgh.harvard.edu

Detailed Description

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo. The investigators aim to establish baseline data in healthy subjects, compare elastic moduli in different tissue types, and measure differences in elastic moduli between keratoconus and normal eyes. If successful, this project will provide useful, previously inaccessible elastic parameters and advance the investigators' understanding of the relationship between the bulk mechanical properties and the microstructure of the human tissue in vivo. This information can ultimately be used to improve the diagnosis and treatment of keratoconus, inflammatory skin diseases, and inflammatory gingiva diseases. More broadly, the technologies developed in this project will have relevance to other potential applications beyond the tissues in this research study.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.