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Purpose

The purpose of this research study is to learn more about lung cancer (NSCLC or SCLC) diagnosed in adults at ages 45 or younger.

Conditions

Eligibility

Eligible Ages
Between 15 Years and 45 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age 45 and under at lung cancer diagnosis - Pathologically confirmed bronchogenic lung carcinoma (NSCLC or SCLC of any stage) at any treatment time point - Provision of written informed consent - Willingness to undergo no more than two (2) peripheral blood draws in a four (4) week period, with no more than 50 ml peripheral blood collected over eight (8) weeks - Individuals under age 18 are eligible for study if they meet defined criteria; in addition, consent for participation must be given by a legal guardian or parent

Exclusion Criteria

  • Individuals who decline to sign consent - Individuals who are unable to give consent or assent and are without a designated healthcare proxy - Compromise of patient diagnosis or staging if tissue is used for research

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Other

Arm Groups

ArmDescriptionAssigned Intervention
Data/Biospecimen Collection Tumor and saliva specimens from participants with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) diagnosed at age 45 or younger
  • Genetic: Data and Specimen Collection
    - Provide research team access to relevant medical records - Answer two (2) short questionnaires at time of consent - Provide up to 5 tubes (37 ml) of blood at or near the time of consent, and/or saliva sample - Consider consenting to other optional parts of the research such as: - Providing additional blood or tissue samples in the future (optional) - Providing permission for obtainment of stored tissue specimens from lung cancer surgeries or biopsies from the pathology departments where they have been stored (optional)

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Jessica Line, MD
617-724-1134
jjlin1@partners.org

More Details

Status
Recruiting
Sponsor
Dana-Farber Cancer Institute

Study Contact

Pasi A Janne, MD, PhD
617-632-6036
Pasi_Janne@dfci.harvard.edu

Detailed Description

This research study looks to enroll as many people diagnosed with lung cancer at 45 years old or younger in order to: - Better understand causes of lung cancer in individuals 45 years old and younger, which is a rare disease - Better estimate lung cancer risks and potential risk factors for lung cancer in individuals 45 years old and younger - Examine tumor (somatic) or normal (germline) genetic changes that may be shared among young lung cancer patients - Improve opportunities for screening and treatment of lung cancer in individuals 45 years old and younger Study procedures will include: - Collecting information from participants' medical record and two (2) short questionnaires - Collecting blood and/or saliva samples - Collecting tumor tissue samples (optional) It is expected that about 500 people will take part in this research study. Participants will be in this study until it closes or the participant withdraws consent.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.