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Purpose

The investigators will test the hypothesis that auditory stimulation (playing quiet sounds during sleep) can normalize brain activity during sleep and improve memory in patients with schizophrenia. The investigators will do this by measuring sleep and memory performance under two conditions separated by one week: receiving auditory stimulation during sleep and not receiving auditory stimulation during sleep. The investigators will study healthy subjects and outpatients with schizophrenia.

Condition

Eligibility

Eligible Ages
Between 18 Years and 50 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

For healthy controls: - Male and female subjects - 18-50 years of age - Proficient in English For schizophrenia patients: - Male and female schizophrenia outpatients - 18-50 years of age - Proficient in English - Able to give informed consent

Exclusion Criteria

  • Pregnant females - Current use of psychotropic medications (healthy controls only) - A history of head injury resulting in prolonged loss of consciousness or other neurological sequelae - IQ <85 - Neurological disorder (including seizure disorder) - Significant hearing or vision loss - Current substance abuse or dependence (nicotine abuse or dependence is not exclusionary) - Any unstable chronic medical condition that affects sleep - Diagnosed sleep disorder

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Other
Masking
Double (Participant, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Schizophrenia 		Adult outpatients with a diagnosis of schizophrenia.
  • Other: Placebo
    Auditory stimulation will not be delivered during the nap
  • Other: Auditory Stimulation
    Auditory stimulation will be delivered during the nap
Experimental
Healthy Controls 		Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use.
  • Other: Placebo
    Auditory stimulation will not be delivered during the nap
  • Other: Auditory Stimulation
    Auditory stimulation will be delivered during the nap

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Dara Manoach, PhD
617-724-6148
manoachlab@gmail.com

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

Lindsey Woodham
617-726-0307
manoachlab@gmail.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.