Sleep Spindles and Memory in Rolandic Epilepsy
Purpose
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Conditions
- Rolandic Epilepsy
- Rolandic Epilepsy, Benign
- Centrotemporal Epilepsy
- Centrotemporal; EEG Spikes, Epilepsy of Childhood
- Epilepsy; Seizure
- Epilepsy
Eligibility
- Eligible Ages
- Between 4 Years and 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Ages 4-18 years 2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist 3. Has EEG with sleep activated centrotemporal spikes 4. Has had at least 1 focal motor or generalized seizure
Exclusion Criteria
- Has abnormal brain MRI 2. Has other unrelated neurological disease 3. Unable to have an MRI/MEG 1. Claustrophobic 2. History of frequent vomiting 3. Permanent metal in body, braces 4. Over MRI weight limit: 350lbs
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Children and adolescents with epilepsy and controls |
Closed loop auditory stimulation during nap |
|
Recruiting Locations
Charlestown, Massachusetts 02129
More Details
- Status
- Recruiting
- Sponsor
- Massachusetts General Hospital
Detailed Description
This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.