Print

Purpose

This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 65 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Males and Females Between Ages of 18 and 65 - Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II - Requiring ECT Treatment as Part of Psychiatric Care

Exclusion Criteria

  • Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia - History of Psychosis - Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months - Severe or Unstable Medical Illness - Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Unipolar Depression Patients diagnosed with Major Depressive Disorder.
  • Device: Electroconvulsive Therapy
    Electrical currents are passed through the brain to intentionally trigger a controlled seizure in order to produce a therapeutic change in neuro-chemistry and circuitry.
Bipolar Depression Patients diagnosed with Bipolar I or II.
  • Device: Electroconvulsive Therapy
    Electrical currents are passed through the brain to intentionally trigger a controlled seizure in order to produce a therapeutic change in neuro-chemistry and circuitry.
Healthy Control Patients without psychiatric diagnoses.

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02129
Contact:
DNN Inbox
617-724-8780
mghdnn@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

DNN Inbox
617-724-8780
mghdnn@mgh.harvard.edu

Detailed Description

This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.