Pulmonary Hemodynamics During Exercise - Research Network
Purpose
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Condition
- Pulmonary Circulation Diseases
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise - Written informed consent of participating subjects after being fully briefed (for prospective analysis)
Exclusion Criteria
- Patients with incomplete hemodynamic data at rest or exercise - Patients without sufficient follow-up data (information on survival / lung transplantation) - advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases - advanced heart failure with pulmonary arterial wedge pressure (PAWP) > 18 mmHg at rest - uncontrolled systemic arterial hypertension (RR values > 160/100 mmHg at rest) - FEV1<50% predicted - TLC<60% predicted
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Retrospective patient cohort |
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Prospective patient cohort |
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Recruiting Locations
Massachusetts General Hospital, Cardiology Division and Pulmonary Unit
Boston, Massachusetts 02114
Boston, Massachusetts 02114
More Details
- Status
- Recruiting
- Sponsor
- Medical University of Graz