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Purpose

This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • All adult patients with a diagnosis of malignant pleural mesothelioma undergoing - diagnostic pleural biopsy - pleuroscopy - and/or VATS resections - Participants must be 18 years of age or older.

Exclusion Criteria

  • Any patient who is found to be unsuitable for - surgery, - treatment - diagnosis,

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Diagnostic
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
MRiS 		- The specimens to be collected will include at least five pleural biopsy samples - MPT test and the CLDN15/VIM test will be performed
  • Other: MPT Test
    molecular expression tests at the RNA level using approximately 7 or more genes with RTPCR, nanostring or similar platforms
  • Other: CLDN15/VIM Test
    molecular expression tests at the RNA level using approximately 7 or more genes with RTPCR, nanostring or similar platforms

Recruiting Locations

Brigham and Women's Hospital
Boston, Massachusetts 02215
Contact:
Raphael Bueno, MD
617-732-5690
rbueno@partners.org

More Details

Status
Recruiting
Sponsor
Dana-Farber Cancer Institute

Study Contact

Raphael Bueno, MD
617-732-5690
rbueno@partners.org

Detailed Description

The purpose of this research study is to test a new method for determining the stage and prognosis of patients with malignant pleural mesothelioma. Currently, it is not possible to accurately determine cancer stage prior to surgery or another treatment. This new method may allow doctors to better classify cancer stage and give a better estimate for prognosis prior to surgery or another treatment. In this research study, the investigators would like to use biopsied tissue to study certain characteristics that will help test the new method for determining cancer stage and estimating prognosis. In this research study, the investigators are... - Obtaining pleural specimens at the time of routine diagnostic biopsy during the participant's standard treatment. - Storing your biopsied tissue - Studying the tissue to determine if the new method of staging and prognosis is accurate and valid

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.