REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness
Purpose
The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI) and electroencephalographic (EEG) technologies for predicting functional outcomes in patients with severe traumatic brain injury (TBI).
Conditions
- Consciousness Disorder
- Coma
- Brain Injuries, Traumatic
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Traumatic Brain Injury - Glasgow Coma Scale score of 3-8 within 24 hours, unconfounded by sedation, paralysis, hypoxia, hypotension, hypothermia, or concurrent medical illness - Clinical evidence of disorder of consciousness defined as coma, VS, or MCS
Exclusion Criteria
- History of prior severe brain injury or dementia - Emergence from MCS at time of initial CRS-R assessment Healthy Subjects: Exclusion Criteria: History of brain injury or neurological disease, psychiatric disease, or any history of diabetes, high blood pressure, heart disease, or kidney disease
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Patient (n=50) | Adults with acute severe traumatic brain injury who undergo advanced neuroimaging and electrophysiological studies while in the intensive care unit and are followed for 6 months post injury. | |
| Healthy (n=25) | Healthy adults with no neurological, psychiatric, or medical disease. |
More Details
- Status
- Completed
- Sponsor
- Massachusetts General Hospital