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Purpose

This project aims to establish a network of spine oncology centers dedicated to prospective multicenter research of patients diagnosed with a primary tumor of the spine and will include a comprehensive prospective clinical database which will serve as a shared research platform. Demographic, clinical, diagnostic, and therapeutic variables will be used to answer questions about survival and local recurrence, as well as questions about adverse events (AEs), morbidity data, and health-related quality of life (HRQOL) outcomes.

Condition

Eligibility

Eligible Ages
All ages
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patient with a current primary spine tumor or history of a primary spine tumor, including tumors within or surrounding the spinal column and/or spinal cord. This includes extradural tumors, intramedullary tumors (i.e. astrocytomas, ependymoma, etc.) and extramedullary tumors (i.e. meningiomas, neurofibromas, schwannomas, etc.). - Informed consent obtained, i.e.: - Ability to understand the content of the patient information/ICF - Willingness and ability to participate in the registry according to the Registry Plan (RP) - Signed and dated EC/IRB approved written informed consent OR - Written consent provided according to the IRB/EC defined and approved procedures for patients who are not able to provide independent written informed consent

Exclusion Criteria

  • Patient diagnosed with a metastatic tumor of the spine.

Study Design

Phase
Study Type
Observational [Patient Registry]
Observational Model
Case-Only
Time Perspective
Prospective

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
John H Shin, MD
Shin.John@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
AO Innovation Translation Center

Study Contact

Benjamin Bretzinger
+41 79 814 01 48
benjamin.bretzinger@aofoundation.org

Detailed Description

Objective: To prospectively investigate variables (clinical, diagnostic, and therapeutic) in patients diagnosed with primary spinal column and cord tumors that are associated with: - survival - local recurrence - morbidity data - patient reported outcomes Outcome measures: Variables applicable to primary spinal column tumor patients which will be collected in the registry include: - Patient details - Treatment status - Details of previous treatment - Diagnosis and biopsy types - Tumor details - Oncological staging - Symptoms - Treatment details - Imaging information We aim to collect the following outcome measures: - Overall survival data - Local disease recurrence data - Morbidity data - Patient reported outcomes: - Euroquol-5D-3L, EQ-5D-Y (if applicable) - Euroquol EQ-5D VAS - Quality of Life - Neck pain numeric rating scale (NRS) - Arm pain NRS - Back pain NRS - Leg Pain NRS - SF-36 version 2 - SOSG Outcome Questionnaire (SOSGOQ) v1.0 and v2.0 - Surverys on patient expectations and satisfaction

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.