Bone Health in Youth With Type 1 Diabetes
Purpose
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls. The investigators will be examining blood and urine hormone levels as well as measures of bone density including DXA and high-resolution peripheral quantitiative computed tomography. The investigators will also be collecting data regarding physical activity via use of wearable accelerometers. The investigators hypothesize that youth with type 1 diabetes will have slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic controls, and that bones of individuals with type 1 diabetes will not respond as well to physical activity. The investigators hypothesize that poor bone accrual will be associated with sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.
Conditions
- Type 1 Diabetes
- Osteoporosis
Eligibility
- Eligible Ages
- Between 6 Years and 20 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age 6-20 years - Out of honeymoon period (cohort with diabetes)
Exclusion Criteria
- BMI<5th percentile for age - BMI>95th percentile for age - Celiac disease - Hyperthyroidism, uncontrolled hypothyroidism - History of significant hepatic disease, renal disease, oncologic disease, cardiovascular disease, psychiatric disease - Anemia (Hgb <11) - Taking medications other than insulin known to affect bone health (including hormonal contraception, glucocorticoids, growth hormone)
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| youth with type 1 diabetes | ||
| healthy controls |
Recruiting Locations
Boston, Massachusetts 02114
More Details
- Status
- Recruiting
- Sponsor
- Massachusetts General Hospital