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Purpose

The ultimate goal of the Barrett's Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett's esophagus and esophageal adenocarcinoma (EAC). We plan to do by developing a registry that will serve as a platform. Examples of analyses could include identifying genetic determinants and biomarkers that predict BE, progression of BE to EAC, as well as the response to therapies.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Barrett's (BE): Patients who have Barrett's esophagus (all stages: Barrett's metaplasia, low-grade dysplasia, high-grade dysplasia) based upon standard endoscopic and histologic criteria. - Adenocarcinoma (EAC): Patients who have esophageal adenocarcinoma. - The control cohort will include patients ages 18 and older with no prior history of BE and EAC. These may include patients who are being seen or have been previously seen at MGH GI Associates for conditions including gastroesophageal reflux disease, peptic esophagitis, eosinophilic esophagitis, esophageal motility disorders such as achalasia and nutcracker esophagus.

Exclusion Criteria

  • Inability or unwillingness to provide blood samples. - History of known bleeding disorders. - Currently awaiting organ transplantation. - Having an acute or severe chronic illness such as congestive heart failure or any other condition that would prohibit performing the endoscopy.

Study Design

Phase
Study Type
Observational [Patient Registry]
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Barrett's Esophagus/Esophageal Adenocarcinoma Patients who have Barrett's esophagus or esophageal adenocarcinoma.
Healthy control

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Katherine Perzan, BA
617-726-1431
kperzan@partners.org

More Details

Status
Unknown status
Sponsor
Massachusetts General Hospital

Study Contact

Katherine Perzan, BA
617-726-1431
kperzan@partners.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.