Mass General - Division of Clinical Research

Eligibility

Eligible Ages

Between 18 Years and 60 Years

Eligible Genders

All

Accepts Healthy Volunteers

Yes

Criteria

A. Healthy Subjects

All healthy subjects will meet the following criteria:

- normal puberty with respect to onset and pace,

- no difficulty with blood draws,

- no prescription medications for at least 2 months with the exception of asthma
medication (albuterol only), hypercholesterolemia medication and psychiatric
medication,

- no illicit drug use or excessive alcohol consumption (>10 drinks/week),

- no history of a medication reaction requiring emergency medical care,

- normal physical exam and laboratory studies within protocol reference ranges.

Additional criteria based on subject population:

1. Healthy Men:

- between 21 and 40 years old,

- normal erectile and ejaculatory function, no history of reproductive disorders,

- testicular volume >15 ml.

2. Healthy women:

- between 21 and 40 years old,

- not breastfeeding or pregnant,

- menstrual cycles between 25 and 35 days in duration with no more than 5 days
variability in cycle duration,

- no evidence for androgen excess (hirsutism or acne),

3. Healthy postmenopausal women:

- between 48 and 60 years old,

- no menstrual periods within the last year,

- previous history of menstrual cycles between 25 and 35 days in duration, with no
more than 5 days variability in cycle duration,

- if applicable, able to undergo washout from hormone therapy,

- no evidence for androgen excess (hirsutism or acne),

- negative screening for Factor V Leiden for those who might receive estradiol
treatment as a part of this study.

B. Subjects with Reproductive Disorders

All subjects with reproductive disorders will meet the following criteria:

- all medical conditions stable and well controlled, medications allowed include asthma
medication (albuterol only), hypercholesterolemia medication and psychiatric
medication,

- no medications known to affect reproductive endocrine function for at least 2 months
except for medications used to treat the subject's reproductive condition,

- no history of a medication reaction requiring emergency medical care,

- no illicit drug use or excessive alcohol consumption (>10 drinks/week),

- for women, not breastfeeding or pregnant,

- if applicable, able to undergo appropriate washout from hormone therapy,

- normal physical exam and laboratory studies within protocol reference ranges,

Additional criteria based on subject population:

1. Men and women with hypogonadotropic hypogonadism,

- 18 years or older,

- Confirmed diagnosis by low sex steroids in the setting of low or inappropriately
normal gonadotropins,

- If needed, additional labs and imaging tests may be performed.

2. Agonadal men,

- Between 18 and 60 years old.