Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

Purpose

The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.

Conditions

  • Heart Failure
  • Heart Failure With Preserved Ejection Fraction

Eligibility

Eligible Ages
Over 30 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • HFpEF criteria 1. Age ≥30 years. 2. Left ventricular ejection fraction ≥50% measured by echocardiography, CMR or MUGA (measured within one year + clinical stability) 3. Definition of HFpEF: signs and/or symptoms of HF, NYHA functional class II-IV, and at least one of the following: 1. Elevated BNP (≥75 pg/ml in sinus rhythm or ≥225 pg/ml in atrial fibrillation/flutter) or NTproBNP (≥225 pg/ml in sinus rhythm or ≥675 in atrial fibrillation/flutter) at baseline. Choice of BNP or NTproBNP is based on availability at each clinical center. 2. Prior HF hospitalization (primary reason for the hospitalization is HF with elevated natriuretic peptide levels [using the thresholds listed above], requiring IV diuresis for HF, or pulmonary edema or pulmonary vascular congestion on chest radiography). 3. Previously documented elevated pulmonary capillary wedge pressure (PCWP) at rest (≥15 mmHg) or during exercise (≥25 mmHg for supine exercise or PCWP/cardiac output ratio ≥2 mmHg/L/min for upright exercise). 4. Elevated H2FPEF score69 (≥5) or HFA-PEFF70 score (≥5). Suspected HFpEF criteria 1. Age ≥30 years. 2. Left ventricular ejection fraction ≥50% measured by echocardiography, CMR or MUGA (measured within one year + clinical stability) 3. Signs and/or symptoms of HF, NYHA functional class II-IV and all of the following: 1. Does not meet BNP or NT-proBNP criteria for HFpEF (above) 2. No prior HF hospitalization meeting HF criteria (above) 3. No previous hemodynamic catheterization documentation of HF (as above)

Exclusion Criteria

  • 1. Inadequate echo or fluoroscopic images. 2. Neck anatomy unfavorable for jugular venous cannulation 3. Therapy with direct oral anticoagulants without cessation for a period (age, renal function, and agent specific) deemed adequate to normalize coagulation according to local clinical guidelines. 4. Previous or ongoing therapy with warfarin with INR ≥ 1.6 measured day before or of EMB 5. Platelet count < 50,000/ml 6. Active bleeding or coagulation disorder 7. Infection or fever 8. Endocarditis 9. Pregnancy 10. Intracardiac thrombus 11. RV Aneurysm 12. Clinically significant tricuspid, pulmonary or aortic valve stenosis 13. Tricuspid or pulmonary mechanical valve prosthesis 14. Left bundle branch block

Study Design

Phase
Study Type
Observational [Patient Registry]
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
HFpEF Participants with HFpEF
Non-HFpEF Participants without HFpEF

Recruiting Locations

Mass General Brigham
Boston, Massachusetts 02114
Contact:
Diane Cocca-Spofford
617-726-8228
dcoccaspofford@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
Northwestern University

Study Contact

Laura Alagna
312-695-6765
heartsharestudy@northwestern.edu