Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Purpose

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Condition

  • Refractory Epilepsy

Eligibility

Eligible Ages
All ages
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation -

Exclusion Criteria

Baseline spike ripple rate < 0.5/min. -

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Basic Science
Masking
Single (Outcomes Assessor)

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Catherine Chu
617-726-6540
cjchu@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

Catherine Chu, MD
617726-6540
cjchu@mgh.harvard.edu