Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

Purpose

This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of exercises. The findings will enhance our understanding of the mechanisms underlying mind-body exercise and facilitate the development of new pain management approaches.

Condition

  • Knee Osteoarthritis

Eligibility

Eligible Ages
Between 45 Years and 75 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Volunteers 45-75 years of age - Meet the Classification Criteria of the American College of Rheumatology for osteoarthritis of the right and/or left knee for at least the past 3 months; - Physically able to participate in the BDJ and stretching control education programs - Willing to complete the 12-week study - Can participate in MRI scan - Ability to read and understand English; English can be a second language provided that the patient feels he or she can understand all the questions used in the assessment measures

Exclusion Criteria

  • Has performed BDJ, Tai Chi, Yoga, other mind-body intervention, physical therapy, or routine exercise (running, cycling, etc.) regularly in the past year - Serious medical conditions limiting ability of patient to participate in the study, such as symptomatic cardiovascular disease, symptomatic pulmonary disease requiring supplemental oxygen, uncontrolled metabolic diseases, severe renal and liver disease - Has had intra-articular steroid injections or reconstructive surgery in the prior 3 months on the affected knee; any intra-articular hyaluronic acid injections in the previous 6 months - Patient Mini-Mental Status Examination score below 24 [293] - Unable to walk without a cane or other assistive device - The intent to undergo surgery during the time of involvement in the study - Plan to permanently relocate from the region during the trial period

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Intervention Model Description
Clinical mechanism study
Primary Purpose
Other
Masking
Double (Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
BDJ + real tDCS
  • Behavioral: BDJ
    BDJ is a mind-body intervention
  • Device: tDCS
    tDCS is a brain stimulation method.
Active Comparator
Exercise + real tDCS
  • Device: tDCS
    tDCS is a brain stimulation method.
  • Other: exercise
    exercise including stretching and other activities.
Active Comparator
BDJ + sham tDCS
  • Behavioral: BDJ
    BDJ is a mind-body intervention
  • Device: sham tDCS
    sham tDCS
Active Comparator
Exercise + sham tDCS
  • Device: sham tDCS
    sham tDCS
  • Other: exercise
    exercise including stretching and other activities.

Recruiting Locations

Massachusetts General Hospital
Charlestown, Massachusetts 02129
Contact:
meixuan Zhu
617-726-5004
mzhu11@mgh.harvard.edu

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

Jian Kong
617-7267893
jkong2@mgh.harvard.edu