HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

Purpose

This research study is evaluating a program that entails a healthcare at home intervention for people with advanced liver disease.

Conditions

  • Cirrhosis
  • End Stage Liver DIsease
  • Liver Cirrhosis
  • Liver Disease Chronic

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Adult patients ≥ 18 years old with diagnosis of cirrhosis based on histology, radiology, and/or elastography presenting to the emergency department or inpatient general medicine service 2. Patients must have one of the following: 1. Ascites (requiring diuretics or serial large volume paracenteses) 2. Hepatic hydrothorax (requiring diuretics) 3. Hepatic encephalopathy (requiring medications)

Exclusion Criteria

All existing MGB home hospital criteria apply, with the following taking precedent for this specific condition 1. History of solid organ transplantation 2. On hemodialysis 3. MELD score > 20 4. Score <10 on Simplified Animal Naming Test (S-ANT1) 5. Current admission for hemodynamically significant GI bleeding or alcohol withdrawal 6. Require routine administration of controlled substances 7. Those deemed ineligible based on the MGH Home Hospital, inpatient medicine or hepatology clinician evaluation

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Health Services Research
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Hepatology Hospital at Home
Patients with advanced liver disease receive hospital-level care in the home setting
  • Behavioral: Hepatology Home Hospital
    The Hepatology Home Hospital intervention entails the following: patient-reported symptoms and vital signs with appropriate triggers for phone calls and home visits, and regular communication with hepatology clinicians regarding care delivered at home to ensure continuity of care.

Recruiting Locations

Massachusetts General Hospital
Boston, Massachusetts 02114
Contact:
Will Munroe, BA
617-726-0161
wlmunroe@mgh.harvard.edu

Massachusetts General Hospital
Boston, Massachusetts 02114

More Details

Status
Recruiting
Sponsor
Massachusetts General Hospital

Study Contact

Nneka Ufere, MD, MSCE
617-643-3408
nufere@partners.org