Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
Purpose
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage (SAH) subjects in a neurocritical care setting. 25 patients will be enrolled, all treated with an active device. The primary efficacy outcomes are reduced aneurysm rupture rate, reduced seizure and seizure-spectrum activity, minimized hemorrhage grades, and increased survival.
Condition
- Subarachnoid Hemorrhage, Aneurysmal
Eligibility
- Eligible Ages
- Between 18 Years and 85 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Male or female, 18-85 years of age - Ruptured aneurysmal SAH confirmed by angiography and repaired by neurosurgical clipping or endovascular occlusion (coiling) - Modified Glasgow Coma Scale (mGCS) score ≥ 10 and Hunt Hess 1-4 within 72 hours of presumed aneurysm rupture - Enrollment and initiation of nVNS treatment must occur within 72 hours of presumed aneurysm rupture - Provide a legally obtained informed consent form from the participant or the legally authorized representative (LAR); telephonic consent is acceptable - Female participants of reproductive age must have a negative pregnancy test result (urine or blood)
Exclusion Criteria
- Use of any concomitant electrostimulation device, including a pacemaker, defibrillator, or deep brain stimulator - No plan to secure aneurysm, defined as aneurysm that has not been surgically or endovascularly treated - Previous neck dissection or radiation - History of carotid artery disease or carotid surgery/dissection - History of secondary or tertiary heart blocks, ventricular tachycardia, or supraventricular tachycardia (SVT; including atrial fibrillation) - Screws, metals, or devices in the neck - Currently participating in an investigational drug or device clinical trial with potential to confound data collection
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Treatment group |
The gammaCore device supplies non-invasive stimulation to the cervical branch of the vagus nerve. |
|
Recruiting Locations
Boston, Massachusetts 02114
More Details
- Status
- Recruiting
- Sponsor
- Massachusetts General Hospital
Detailed Description
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage (SAH). The hypothesis is that two 2-minute non-invasive stimulations of the cervical branch of the vagus nerve with nVNS, 3 times daily (TID), is a safe, practical, and potentially effective treatment after SAH in the neurocritical care setting. After diagnosis and surgical repair of the SAH, patients admitted to the Neuroscience Intensive Care Unit (NeuroICU) at Massachusetts General Hospital (MGH) will be screened for eligibility. Upon providing informed consent, eligible patients will be enrolled, begin the treatment protocol, and will be monitored. Data collection will be completed using automated systems, electronic reports, and manual collection before, during, and after nVNS. The primary objective is to examine the safety, feasibility, and possible efficacy of nVNS as a treatment after aneurysmal subarachnoid hemorrhage (SAH). Safety will be assessed by the incidence of severe adverse device events (SADEs) following nVNS. Feasibility of the nVNS implementation will be evaluated by the ability to deliver >85% of doses per protocol, report of minimal interference with current standard of care treatments and procedures in in the NeuroICU, and beginning of treatment within 72 hours of presumed aneurysm rupture. Efficacy of nVNS will be explored using the following assessments: - subject disability measured using mRS at 10 days (or discharge) and 90 days after SAH - effects on EEG, TCD, and ICP before, during, and after nVNS - DCI/ischemic stroke detected by CT scans and/or angiography - HR (heart rate), HR variability, and BP before, during, and after nVNS The study period starts within 72 hours of presumed aneurysm rupture and ends at 10 days or discharge, if sooner. The PI and co-investigators will conduct safety monitoring of this small, single-site, low-risk pilot study on a continuous basis, ensuring adherence to the Mass General Brigham (MGB) Institutional Review Board (IRB) guidelines accordingly.