Search Clinical Trials
Sponsor Condition of Interest |
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Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
Edwards Lifesciences
Tricuspid Regurgitation
Tricuspid Valve Insufficiency
Tricuspid Valve Disease
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair
System in patients with symptomatic severe tricuspid regurgitation who have been
determined to be at an intermediate or greater estimated risk of mortality with tricuspid
valve surgery by the cardiac surgeon with... expand
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team Type: Interventional Start Date: Dec 2019 |
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
Icahn School of Medicine at Mount Sinai
Atrial Fibrillation
Stroke
Bleeding
The primary objective of this study is to evaluate the effectiveness (prevention of
thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC)
to background antiplatelet therapy in patients who develop new-onset post-operative
atrial fibrillation (POAF) after isolated... expand
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their baseline risk profile and their treatment strategy in terms of anticoagulants or antiplatelets received. These patients will also be asked to fill out a brief decliner survey. Type: Interventional Start Date: Dec 2019 |
Developing Fast Pediatric Imaging
Boston Children's Hospital
Pediatric Low-grade Gliomas
This research study is evaluating the investigational software for magnetic resonance
imaging (MRI) systems and techniques to process magnetic resonance (MR) images expand
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images Type: Interventional Start Date: Apr 2019 |
Skilled Nursing Facility Care at Home
Brigham and Women's Hospital
Skilled Nursing Facility
Rehabilitation
We will perform a parallel-group multicenter patient-level randomized controlled
evaluation of skilled nursing facility care at home. Patients typically referred to a
skilled nursing facility following hospitalization will be eligible for enrollment.
Instead of admission to a skilled nursing facility,... expand
We will perform a parallel-group multicenter patient-level randomized controlled evaluation of skilled nursing facility care at home. Patients typically referred to a skilled nursing facility following hospitalization will be eligible for enrollment. Instead of admission to a skilled nursing facility, participants will receive care from a technology-enabled team in their own homes or will be allocated to receive care in a traditional skilled nursing facility setting. Type: Interventional Start Date: Jun 2024 |
A Study of EDG-7500 in Adults with Hypertrophic Cardiomyopathy (CIRRUS-HCM)
Edgewise Therapeutics, Inc.
Hypertrophic Cardiomyopathy
This study is being conducted in order to understand the safety and effects of different
doses of EDG-7500 as a single dose in adults with obstructive hypertrophic cardiomyopathy
and as multiple doses in adults with obstructive or nonobstructive hypertrophic
cardiomyopathy. expand
This study is being conducted in order to understand the safety and effects of different doses of EDG-7500 as a single dose in adults with obstructive hypertrophic cardiomyopathy and as multiple doses in adults with obstructive or nonobstructive hypertrophic cardiomyopathy. Type: Interventional Start Date: Apr 2024 |
Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
MGH Institute of Health Professions
Copd
COPD Exacerbation
COPD Bronchitis
Emphysema or COPD
Chronic Lung Disease
The goal of this pilot clinical trial is to compare telehealth and onsite supervised
maintenance exercise program for adults with Chronic Lung Disease.
The specific aims of the study are:
- To compare 8-week supervised maintenance program delivered onsite and via tele-rehab
with no maintenance... expand
The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with Chronic Lung Disease. The specific aims of the study are: - To compare 8-week supervised maintenance program delivered onsite and via tele-rehab with no maintenance for patients with Chronic Lung Disease following discharge from traditional exercise or physical therapy or onsite outpatient rehabilitation programs on clinical outcomes (dyspnea, exercise capacity, physical function, physical activity, and quality of life) at 8 weeks and 4-months post-intervention. - To compare the differences in dyspnea, exercise capacity, physical function, physical activity, and quality of life between an 8-week maintenance program delivered onsite and via tele-rehab at 8-weeks and 4-months post-intervention in patients with Chronic Lung Disease following discharge from traditional onsite outpatient rehabilitation. Participants in both intervention groups (onsite and tele-rehab) will undergo a baseline onsite assessment followed by an 8-week supervised exercise intervention either onsite or in a telehealth setting. Control group will receive biweekly check in calls, but no active intervention. Type: Interventional Start Date: Sep 2023 |
Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy
Massachusetts General Hospital
Myotonic Dystrophy Type 1
Myotonic dystrophy is associated with central sleep apnea, excessive daytime sleepiness,
diminished working memory, impaired visuospatial skills, and deficits in problem-solving
skills.
Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds and protects the
brain.
Changes in the... expand
Myotonic dystrophy is associated with central sleep apnea, excessive daytime sleepiness, diminished working memory, impaired visuospatial skills, and deficits in problem-solving skills. Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds and protects the brain. Changes in the composition of CSF can serve as early indicators of changes in brain activity and function. The purpose of this research is to learn about myotonic dystrophy by examining cerebrospinal fluid and brain activity in participants. The tests will be low risk and are well tolerated. The information that we gather from this study may help us evaluate, prevent, diagnose, treat, and improve our understanding of myotonic dystrophy. Funding Source- FDA OOPD Type: Observational Start Date: Aug 2022 |
Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
Syndax Pharmaceuticals
Colorectal Cancer
Solid Tumors
This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor
activity of revumenib in participants with colorectal cancer (CRC) or other solid tumors
who have failed at least 1 prior line of therapy. expand
This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of revumenib in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy. Type: Interventional Start Date: Apr 2023 |
Building Resiliency Among Caregivers of Curvivors and Metavivors
Massachusetts General Hospital
Stress
Cancer Diagnosis
Distress, Emotional
The main purpose of this research study is to assess the feasibility and participants'
satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency
Program (SMART-3RP) and compare this treatment with SMART-3RP versus referral to a
group-based, online support group to see which... expand
The main purpose of this research study is to assess the feasibility and participants' satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency Program (SMART-3RP) and compare this treatment with SMART-3RP versus referral to a group-based, online support group to see which is better for improving resilience and decreasing distress of participants with cancer and their caregivers. The name of the study intervention involved in this study is: Smart-3RP (virtual, mind-body group treatment program). Type: Interventional Start Date: Jun 2023 |
Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation...
Oryzon Genomics S.A.
Acute Myeloid Leukemia, in Relapse
Acute Myeloid Leukemia Refractory
Iadademstat is being studied as a treatment for subjects with Relapsed or Refractory
Acute Myeloid Leukemia (R/R AML) with FMS-like tyrosine kinase mutation (FLT3 mut+).
During the trial, iadademstat will be given in combination with gilteritinib, a drug that
is already approved to treat patients... expand
Iadademstat is being studied as a treatment for subjects with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) with FMS-like tyrosine kinase mutation (FLT3 mut+). During the trial, iadademstat will be given in combination with gilteritinib, a drug that is already approved to treat patients with FLT3-mutated R/R AML. Type: Interventional Start Date: Nov 2022 |
A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas
Novartis Pharmaceuticals
Metastatic Uveal Melanoma
This is a FIH, phase I/II, open label, multi-center study of DYP688 as a single agent.
The purpose of this study is to characterize the safety, tolerability, and anti-tumor
activity of DYP688 as a single agent in patients with metastatic uveal melanoma (MUM) and
other melanomas harboring GNAQ/11 mutations. expand
This is a FIH, phase I/II, open label, multi-center study of DYP688 as a single agent. The purpose of this study is to characterize the safety, tolerability, and anti-tumor activity of DYP688 as a single agent in patients with metastatic uveal melanoma (MUM) and other melanomas harboring GNAQ/11 mutations. Type: Interventional Start Date: Jul 2022 |
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study)
Ono Pharmaceutical Co. Ltd
Refractory Primary Central Nervous System Lymphoma
Primary CNS Lymphoma
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib
monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in
combination with one of two different high dose methotrexate based regimens
(methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/
vincristine)... expand
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in combination with one of two different high dose methotrexate based regimens (methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/ vincristine) as first line therapy in patients with newly diagnosed, treatment naïve PCNSL (Part B) Type: Interventional Start Date: Dec 2021 |
Estrogen Administration for the Treatment of NASH in Postmenopausal Women
Massachusetts General Hospital
NASH - Nonalcoholic Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States.
Despite this, the treatment options remain limited. Preclinical and preliminary clinical
data suggest that estrogen deficiency plays an important role in the pathology of
steatosis, inflammation and fibrosis in non-alcoholic... expand
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estrogen deficiency plays an important role in the pathology of steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Post-menopausal women are a growing population with particularly high risk of NASH due to their lack of estrogen. This study will examine the effect of estradiol on hepatic fibrosis and fat in post-menopausal women with NASH. Type: Interventional Start Date: Dec 2021 |
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
Stephanie B. Seminara, MD
Hypogonadotropic Hypogonadism
The goal of this study is to develop novel treatments for patients with a condition
called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin. expand
The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin. Type: Interventional Start Date: Jan 2021 |
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
Massachusetts General Hospital
Obsessive-Compulsive Disorder
Generalized Anxiety Disorder
Major Depressive Disorder
The investigators are conducting this study to learn more about the cognitive and
attentional processes among individuals with three types of repetitive negative thinking
(RNT): mental rituals (as seen in obsessive compulsive disorder, OCD), worries (as seen
in generalized anxiety disorder, GAD),... expand
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive disorder, OCD), worries (as seen in generalized anxiety disorder, GAD), and ruminations (as seen in major depressive disorder, MDD). Specifically, the investigators are studying whether psychological treatment can help people with RNT who have trouble stopping unwanted thoughts and shifting their attention. Type: Interventional Start Date: Apr 2021 |
Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent...
VBI Vaccines Inc.
Glioblastoma Multiforme
The purpose of this study is to assess the safety and tolerability of VBI-1901 in
subjects with recurrent malignant gliomas (glioblastoma, or GBM). expand
The purpose of this study is to assess the safety and tolerability of VBI-1901 in subjects with recurrent malignant gliomas (glioblastoma, or GBM). Type: Interventional Start Date: Dec 2017 |
Permissive Hypotension After Cardiac Surgery
Massachusetts General Hospital
Surgery
The objective of this pilot randomized controlled trial is to demonstrate the feasibility
of implementing a pragmatic clinical trial randomizing patients to permissive hypotension
versus usual care and to determine the impact of permissive hypotension on vasopressor
exposure, ICU length of stay, markers... expand
The objective of this pilot randomized controlled trial is to demonstrate the feasibility of implementing a pragmatic clinical trial randomizing patients to permissive hypotension versus usual care and to determine the impact of permissive hypotension on vasopressor exposure, ICU length of stay, markers of end organ perfusion, and clinically relevant patient outcomes. The data collected from this pilot study will be used as preliminary data for study design and grant applications for a larger multicenter randomized controlled trial. Type: Interventional Start Date: Apr 2024 |
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Fog Pharmaceuticals, Inc.
Cancer
Colorectal Cancer
Solid Tumor
Locally Advanced Solid Tumor
Metastatic Cancer
The goal of this clinical trial is to determine if FOG-001 is safe and effective in
participants with locally advanced or metastatic cancer. expand
The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer. Type: Interventional Start Date: May 2023 |
Delayed Tolerance Through Mixed Chimerism
Massachusetts General Hospital
Kidney Failure
Kidney Transplant; Complications
Chimera
This study will examine the safety and effectiveness of a bone marrow transplant after
kidney transplant (from either a living or deceased donor). An investigational medication
and other treatments will be given prior to and after the transplant to help protect the
transplanted kidney from being attacked... expand
This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being attacked by the body's immune system Type: Interventional Start Date: Oct 2023 |
Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation
Mirati Therapeutics Inc.
Solid Tumor
Advanced Solid Tumor
Non-small Cell Lung Cancer
Colo-rectal Cancer
Pancreatic Adenocarcinoma
A Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation. expand
A Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation. Type: Interventional Start Date: Mar 2023 |
A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With Select Solid Tumors
Totus Medicines
Colorectal Cancer
Gastric Cancer
HER2-negative Breast Cancer
Non-small Cell Lung Cancer
Squamous Cell Carcinoma of Head and Neck
The goal of this clinical trial is to evaluate the safety of TOS-358 in adults with
select solid tumors who meet study enrollment criteria. The main questions it aims to
answer are:
1. what is the maximum tolerated dose and recommended dose for phase 2?
2. how safe and tolerable is TOS-358... expand
The goal of this clinical trial is to evaluate the safety of TOS-358 in adults with select solid tumors who meet study enrollment criteria. The main questions it aims to answer are: 1. what is the maximum tolerated dose and recommended dose for phase 2? 2. how safe and tolerable is TOS-358 at different dose levels when taken orally once or twice per day? Type: Interventional Start Date: Feb 2023 |
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Massachusetts General Hospital
Major Depressive Disorder
Anxiety Depression
HIV
This study will determine the effects of pregnenolone on brain function, inflammation and
depressive symptoms in people with HIV who have depression. Participants in this study
will receive a pill of either pregnenolone or placebo, and can stay on their current
antidepression medications. Brain imaging... expand
This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications. Brain imaging and behavioral assessments will be performed during the study. Type: Interventional Start Date: Mar 2023 |
Computational Neuroscience of Language Processing in the Human Brain
Massachusetts General Hospital
Language
Epilepsy
Language is a signature human cognitive skill, but the precise computations that support
language understanding remain unknown. This study aims to combine high-quality human
neural data obtained through intracranial recordings with advances in computational
modeling of human cognition to shed light... expand
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech. Type: Interventional Start Date: Apr 2021 |
FOLFIRINOX + 9-Ing-41 + Losartan In Pancreatic Cancer
Colin D. Weekes, M.D., PhD
Pancreatic Adenocarcinoma
Pancreatic Adenocarcinoma Metastatic
The purpose of this study is to find out if an experimental drug will prevent metastatic
pancreatic adenocarcinoma from becoming resistant to standard treatment for the disease.
The names of the study drugs involved in this study are:
- 9-ING-41
- Losartan
- Ferumoxytol
-... expand
The purpose of this study is to find out if an experimental drug will prevent metastatic pancreatic adenocarcinoma from becoming resistant to standard treatment for the disease. The names of the study drugs involved in this study are: - 9-ING-41 - Losartan - Ferumoxytol - FOLFIRINOX (made up of 4 different drugs): - 5-Fluorouracil (5-FU) - Oxaliplatin - Irinotecan - Leucovorin Type: Interventional Start Date: Mar 2022 |
A Phase 1/2 Study of DCC-3116 in Patients With RAS/MAPK Pathway Mutant Solid Tumors
Deciphera Pharmaceuticals, LLC
Non-Small Cell Lung Cancer
Advanced Solid Tumor
Metastatic Solid Tumor
This is a Phase 1/2, multicenter, open label, first in human (FIH) study of DCC-3116 as
monotherapy, and in combination with trametinib, binimetinib, or sotorasib in patients
with advanced or metastatic solid tumors with RAS/MAPK pathway mutation. The study
consists of 2 parts, a dose-escalation phase,... expand
This is a Phase 1/2, multicenter, open label, first in human (FIH) study of DCC-3116 as monotherapy, and in combination with trametinib, binimetinib, or sotorasib in patients with advanced or metastatic solid tumors with RAS/MAPK pathway mutation. The study consists of 2 parts, a dose-escalation phase, and an expansion phase. Type: Interventional Start Date: Jun 2021 |
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