Search Clinical Trials
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Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration
Massachusetts General Hospital
Postmenopausal Osteoporosis
The purpose of this study is to examine, via iliac crest bone biopsies, the mechanism of
combined teriparatide and denosumab on the bone of postmenopausal osteoporotic women after 3
months of treatment.
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The purpose of this study is to examine, via iliac crest bone biopsies, the mechanism of combined teriparatide and denosumab on the bone of postmenopausal osteoporotic women after 3 months of treatment. Type: Interventional Start Date: Oct 2019 |
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed...
National Cancer Institute (NCI)
B Acute Lymphoblastic Leukemia
B Lymphoblastic Lymphoma
Down Syndrome
This phase III trial studies how well blinatumomab works in combination with chemotherapy in
treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or
B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as
blinatumomab,... expand
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin decreases the toxic effects of methotrexate. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. Type: Interventional Start Date: Jun 2019 |
Sleep for Stroke Management and Recovery Trial
University of Michigan
Ischemic Stroke
Sleep Apnea
Sleep Apnea, Obstructive
TIA
Stroke
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA)
with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA
(1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after... expand
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke. Type: Interventional Start Date: May 2019 |
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in...
Novartis Pharmaceuticals
Early Breast Cancer
A phase III multi-center, randomized, open-label trial to evaluate efficacy and safety of
ribociclib with endocrine therapy as adjuvant treatment in patients with HR+/HER2- Early
Breast Cancer
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A phase III multi-center, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as adjuvant treatment in patients with HR+/HER2- Early Breast Cancer Type: Interventional Start Date: Dec 2018 |
Vagus Nerve Stimulation and Stress Reduction Training for Migraine
Massachusetts General Hospital
Migraine
This study design has two components: 1) a cross-sectional assessment of brain activity and
inflammation in migraine patients compared to healthy controls and 2) an assessment of 8
weeks of a combination therapy approach to treating migraine.
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This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine. Type: Interventional Start Date: Aug 2019 |
IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic...
Massachusetts General Hospital
Acute Myeloid Leukemia
Chronic Myelomonocytic Leukemia
This research study is studying a targeted therapy drug as a possible treatment for IDH2
mutant acute myeloid leukemia or chronic myelomonocytic leukemia while undergoing
hematopoietic stem cell transplantation.
The drug involved in this study is:
-Enasidenib.... expand
This research study is studying a targeted therapy drug as a possible treatment for IDH2 mutant acute myeloid leukemia or chronic myelomonocytic leukemia while undergoing hematopoietic stem cell transplantation. The drug involved in this study is: -Enasidenib. Type: Interventional Start Date: Jul 2018 |
SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
Syntrix Biosystems, Inc.
Melanoma Stage III
Melanoma Stage IV
Cancers attract myeloid-derived suppressor cells (MDSCs) that prevent our own immune
responses from destroying the cancer. This study will be the first study to begin to
determine if the newly discovered drug SX-682 can block cancers from attracting MDSCs. This
first study... expand
Cancers attract myeloid-derived suppressor cells (MDSCs) that prevent our own immune responses from destroying the cancer. This study will be the first study to begin to determine if the newly discovered drug SX-682 can block cancers from attracting MDSCs. This first study will enroll participants with melanoma, as melanoma cancer has been shown to be able to attract MDSCs. The study will begin to determine if SX-682 is a safe and effective treatment of melanoma. It is thought that SX-682 will block MDSCs from going to the cancer, and thus will allow a patient's own immune system to attack the cancer. The first participants enrolled in the study will receive for 21 days SX-682 as monotherapy. After 21 days participants will receive pembrolizumab therapy (an approved immunotherapy for melanoma) and will remain in the study for evaluations for 3 months. After these participants complete the monotherapy stage, the next participants will receive SX-682 and pembrolizumab together as combination therapy. These participants will receive the combination therapy and be evaluated in the study for approximately 2 years. Type: Interventional Start Date: Jun 2019 |
Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions...
W.L.Gore & Associates
Aortic Aneurysm, Thoracic
Aorta, Lesion
The objective of this study is to determine whether the GORE® TAG® Thoracic Branch
Endoprosthesis is safe and effective in treating lesions of the aortic arch and descending
thoracic aorta.
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The objective of this study is to determine whether the GORE® TAG® Thoracic Branch Endoprosthesis is safe and effective in treating lesions of the aortic arch and descending thoracic aorta. Type: Interventional Start Date: Aug 2016 |
A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis
Incyte Corporation
MPN (Myeloproliferative Neoplasms)
The purpose of this study is to evaluate the safety, tolerability, and efficacy of the
combination of parsaclisib and ruxolitinib in subjects with myelofibrosis.
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The purpose of this study is to evaluate the safety, tolerability, and efficacy of the combination of parsaclisib and ruxolitinib in subjects with myelofibrosis. Type: Interventional Start Date: Feb 2017 |
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors,...
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm
Bladder Carcinoma
Breast Carcinoma
Cervical Carcinoma
Colon Carcinoma
This phase II MATCH trial studies how well treatment that is directed by genetic testing
works in patients with solid tumors or lymphomas that have progressed following at least one
line of standard treatment or for which no agreed upon treatment approach exists. Genetic
tests... expand
This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Type: Interventional Start Date: Aug 2015 |
Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease
Massachusetts General Hospital
Parkinson Disease
Parkinson
The goal of this research is to determine (1) the feasibility of tethered capsule OCT
esophageal imaging in the Parkinson's Disease population; (2) the morphologic changes in the
enteric nervous system of the esophagus in patients with Parkinson's disease.
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The goal of this research is to determine (1) the feasibility of tethered capsule OCT esophageal imaging in the Parkinson's Disease population; (2) the morphologic changes in the enteric nervous system of the esophagus in patients with Parkinson's disease. Type: Observational Start Date: May 2019 |
Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe
Massachusetts General Hospital
Inflammatory Disease
Permeability; Increased
Crohn Disease
Inflammatory Bowel Diseases
Environmental Enteropathy
The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a
measurement tool for gut permeability
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The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a measurement tool for gut permeability Type: Interventional Start Date: Oct 2020 |
Multidisciplinary Intervention In Chronic GVHD
Massachusetts General Hospital
Stem Cell Transplant Complications
Graft Vs Host Disease
Coping Skills
Quality of Life
This research is being done to evaluate the feasibility and efficacy of a multidisciplinary,
patient-centered intervention, Horizons Program, versus minimally enhanced standard care to
improve quality of life, symptom burden and psychological distress of adults who received an... expand
This research is being done to evaluate the feasibility and efficacy of a multidisciplinary, patient-centered intervention, Horizons Program, versus minimally enhanced standard care to improve quality of life, symptom burden and psychological distress of adults who received an allogeneic hematopoietic stem cell transplant and developed graft versus-host disease (GVHD). Type: Interventional Start Date: Aug 2020 |
First Heroes: Engaging Fathers in the First 1000 Days
Massachusetts General Hospital
Obesity, Childhood
Overweight and Obesity
Social Determinants of Health
Physical Activity
Feeding Behavior
The First Heroes study plans to influence weight and health trajectories, modify disease
risk, and improve health care services for mother-father-infant triads from racial/ethnic
minority and health disparity populations.
This study is a two-arm, randomized controlled trial... expand
The First Heroes study plans to influence weight and health trajectories, modify disease risk, and improve health care services for mother-father-infant triads from racial/ethnic minority and health disparity populations. This study is a two-arm, randomized controlled trial recruiting from Massachusetts General Hospital (MGH) obstetrics practices. This study will enroll 250 father-mother dyads in the second trimester of pregnancy and intervene through their offspring's 1-year birthday. Each mother-father dyad participating will be randomly assigned to one of two arms: 1. Obstetric and Pediatric Standard of Care + New Parent Engagement Intervention Arm or; 2. Obstetric and Pediatric Standard of Care + Safety Control Arm. Type: Interventional Start Date: Aug 2020 |
Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies
Aprea Therapeutics
Bladder Cancer
Gastric Cancer
Non Small Cell Lung Cancer
NSCLC
Urothelial Carcinoma
A phase 1/2, open-label, study to determine the safety and preliminary efficacy of APR-246 in
combination with pembrolizumab in subjects with solid tumor malignancies. The study will
include a safety lead-in portion followed by a phase 2 expansion portion in specific disease... expand
A phase 1/2, open-label, study to determine the safety and preliminary efficacy of APR-246 in combination with pembrolizumab in subjects with solid tumor malignancies. The study will include a safety lead-in portion followed by a phase 2 expansion portion in specific disease groups. Type: Interventional Start Date: Jun 2020 |
Prolonged Nightly Fasting in Breast Cancer Survivors
Massachusetts General Hospital
Fasting
Breast Cancer
Survivorship
Breast Cancer Recurrent
This study is being done to examine whether fasting for 13 hours every night is feasible and
if it can help breast cancer survivors lose weight and improve their health.
- Previous studies have found that women who are overweight or obese when their breast
cancer... expand
This study is being done to examine whether fasting for 13 hours every night is feasible and if it can help breast cancer survivors lose weight and improve their health. - Previous studies have found that women who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk of their breast cancer recurring. Recent research suggests that prolonged nighttime fasting (>13 hours) may improve the risk of recurrence for breast cancer. - This study will examine if fasting for 13 hours per night is doable for participants and will also study what the effect of fasting is on quality of life, mood, fatigue, body size, and markers of health in the blood. Type: Interventional Start Date: Jul 2020 |
Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene...
National Cancer Institute (NCI)
Recurrent Adrenal Gland Pheochromocytoma
Recurrent Ectomesenchymoma
Recurrent Ependymoma
Recurrent Ewing Sarcoma
Recurrent Hepatoblastoma
This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients
with solid tumors that have recurred or spread to other places in the body (advanced),
lymphoma, or histiocytic disorders, that have a genetic alteration in the gene HRAS.
Tipifarnib... expand
This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have recurred or spread to other places in the body (advanced), lymphoma, or histiocytic disorders, that have a genetic alteration in the gene HRAS. Tipifarnib may block the growth of cancer cells that have specific genetic changes in a gene called HRAS and may reduce tumor size. Type: Interventional Start Date: Jul 2020 |
To Assess the Efficacy and Safety of RVT-1401 in the Treatment of Warm Autoimmune Hemolytic Anemia (ASCEND-WAIHA).
Immunovant Sciences GmbH
Warm Autoimmune Hemolytic Anemia
This is a Phase 2 non-randomized, open-label study to investigate the efficacy, safety and
tolerability of RVT-1401 in patients with Warm Autoimmune Hemolytic Anemia.
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This is a Phase 2 non-randomized, open-label study to investigate the efficacy, safety and tolerability of RVT-1401 in patients with Warm Autoimmune Hemolytic Anemia. Type: Interventional Start Date: Aug 2020 |
Gluten Challenge Study in Celiac Disease Participants (MK-0000-402)
Merck Sharp & Dohme Corp.
Celiac Disease
This is a gluten challenge study to characterize peripheral blood and intestinal gluten
specific cluster of differentiation 4 glycoprotein (CD4+) thymus lymphocyte (T cell) subsets
in participants with Celiac Disease
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This is a gluten challenge study to characterize peripheral blood and intestinal gluten specific cluster of differentiation 4 glycoprotein (CD4+) thymus lymphocyte (T cell) subsets in participants with Celiac Disease Type: Interventional Start Date: Aug 2020 |
Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer:...
Massachusetts General Hospital
Breast Cancer
This research is to evaluate the effectiveness of Talazoparib as a potential treatment for
metastatic breast cancer with a BRCA 1 or BRCA 2 mutation.
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This research is to evaluate the effectiveness of Talazoparib as a potential treatment for metastatic breast cancer with a BRCA 1 or BRCA 2 mutation. Type: Interventional Start Date: Sep 2021 |
Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell...
National Cancer Institute (NCI)
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Double-Expressor Lymphoma
EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
This phase II/III trial tests whether it is possible to decrease the chance of high-grade
B-cell lymphomas returning or getting worse by adding a new drug, venetoclax to the usual
combination of drugs used for treatment. Venetoclax may stop the growth of cancer cells by
blocking... expand
This phase II/III trial tests whether it is possible to decrease the chance of high-grade B-cell lymphomas returning or getting worse by adding a new drug, venetoclax to the usual combination of drugs used for treatment. Venetoclax may stop the growth of cancer cells by blocking a protein called Bcl-2. Drugs used in usual chemotherapy, such as rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with usual chemotherapy may work better than usual chemotherapy alone in treating patients with high-grade B-cell lymphomas, and may increase the chance of cancer going into remission and not returning. Type: Interventional Start Date: Aug 2019 |
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas
Massachusetts General Hospital
Neurological Cancer
this research study is evaluating the highest dose of ASTX727 that can be administered safely
to recurrent/progressive non-enhancing IDH mutant gliomas patients.
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this research study is evaluating the highest dose of ASTX727 that can be administered safely to recurrent/progressive non-enhancing IDH mutant gliomas patients. Type: Interventional Start Date: Jul 2019 |
Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear
Massachusetts General Hospital
Acetabular Labrum Tear
Femoro Acetabular Impingement
Chondral Defect
Bone Marrow Aspirate Concentrate
Mesenchymal Stem Cell
Introduction:
Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and
chondrolabral junction. Additionally, it has been proposed that disruption of hip
biomechanics resulting from a labral tear causes a faster progression towards osteoarthritis... expand
Introduction: Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and chondrolabral junction. Additionally, it has been proposed that disruption of hip biomechanics resulting from a labral tear causes a faster progression towards osteoarthritis (OA). This progression has been observed to begin with breakdown of the chondrolabral junction with later development of diffuse osteoarthritis. Use of hip arthroscopy has increased dramatically in recent years to treat symptomatic labral tears and potentially avoid the morbidity and cost associated with hip osteoarthritis. Correction of labral pathology presents a technical challenge and many techniques currently exist. Increased understanding of the structure-functional relationship dictated by labral anatomy has led to the development of methods aimed at restoring functional anatomy by re-establishing the labrum's native position and contour on the rim of the acetabulum. Therefore, akin to repairing a torn meniscus in the knee, restoring the anatomic footprint of a torn labrum will reconstitute normal joint biomechanics. Despite the advances in techniques for labral repair, strategies for mitigating or repairing damage to the chondrolabral junction do not yet exist. This area has been shown to consist of hyaline and fibro cartilage. Many techniques for cartilage repair exist, although most are not feasible due to technical challenges specific to the hip joint. The management of articular cartilage defects is one of the most challenging clinical problems for orthopaedic surgeons. Articular cartilage has a limited intrinsic healing capacity, and pathology frequently results in gradual tissue deterioration. Currently, the standard surgical intervention for end-stage degenerative joint pathology is total joint replacement. Early surgical interventions for symptomatic cartilage lesions including cell based therapies such as autologous chondrocyte implantation (ACI), bone marrow aspirate concentrate (BMAC) implantation, or microfracture have been suggested to restore normal joint congruity and minimize further joint deterioration. Techniques such as ACI, which have been successfully used in the knee joint, have limited application in the hip due to the technical difficulties of open procedures. Type: Observational Start Date: Jun 2017 |
Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain
Massachusetts General Hospital
Back Pain, Low
In this research, the study team will use brain imaging to evaluate the presence of
neuroinflammation in the brains and spinal cords of patients with low back pain, and whether
CBD effects levels of neuroinflammation. The efficacy of CBD use for low back pain treatment
will... expand
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain, and whether CBD effects levels of neuroinflammation. The efficacy of CBD use for low back pain treatment will also be evaluated by observing whether CBD administration will reduce neuroinflammation and low back pain symptoms. Type: Interventional Start Date: Nov 2019 |
Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation...
Massachusetts General Hospital
Other Cancer
This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans
Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT).
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This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT). Type: Interventional Start Date: Apr 2019 |