HCV Post-Exposure Prophylaxis for Health Care Workers
Purpose
This is an unblinded, observational trial of sofosbuvir-velpatasvir in adult health care workers who are exposed to hepatitis C virus from needlestick injury with hollow-bore needles.
Condition
- Hepatitis C
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Healthcare worker with exposure through needlestick injury with hollow-bore needles to source patients who are HCV positive - Healthcare worker must be HCV Ab-
Exclusion Criteria
- HCV Ab positive - HCV Ab negative and HCV RNA greater than 1000 IU/ml - Active malignancy - Positive urine pregnancy test
Study Design
- Phase
- Phase 4
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Prevention
- Masking
- None (Open Label)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental Treatment with Sofosbuvir/Velpatasvir |
14 days of treatment with Sofosbuvir/Velpatasvir tablet |
|
More Details
- Status
- Withdrawn
- Sponsor
- Massachusetts General Hospital
Study Contact
Detailed Description
The goal of this study is to assess the safety and tolerability of the use of sofosbuvir-velpatasvir in the setting of post-exposure prophylaxis among Health Care Workers exposed to HCV from needlestick injury with hollow-bore needles